Các nhà khoa học tìm ra cách chữa bệnh mù lòa bằng liệu pháp gene

Các nhà khoa học tìm ra cách chữa bệnh mù lòa bằng liệu pháp gene


Bệnh mù lòa có thể chữa được nhờ việc sử dụng liệu pháp gene để lập trình lại các tế bào nằm trong võng mạc nhằm giúp cho những tế bào này có khả năng “bắt sáng”.


Đây là kết quả nghiên cứu mới của các nhà khoa học thuộc Đại học Oxford (Anh) được công bố ngày 3/10.

Các bệnh về thoái hóa võng mạc mang tính di truyền như viêm võng mạc sắc tố có thể làm cho thị lực kém dần và dẫn đến mù lòa. Đây là nguyên nhân gây mù lòa phổ biến nhất ở những người trong độ tuổi thanh niên.

Các nhà khoa học tìm ra cách chữa bệnh mù lòa bằng liệu pháp gene
Bệnh thoái hóa võng mạc là nguyên nhân gây mù lòa phổ biến nhất ở những người trong độ tuổi thanh niên.

Tuy nhiên, cho dù thị lực có kém đi thì trong võng mạc vẫn còn nguyên vẹn những tế bào không có khả năng tiếp nhận kích thích ánh sáng.

Một nhóm nhà khoa học của Đại học Oxford đã sử dụng một loại virus biến đổi gene để cấy một gene mới quy định việc sản sinh protein có khả năng tiếp nhận kích thích ánh sáng melanopsin vào những tế bào trên ở những con chuột bị mù do viêm võng mạc sắc tố và theo dõi những con chuột này trong hơn 1 năm. Họ thấy rằng trong suốt thời gian này, những con chuột trên đã nhìn thấy các đồ vật xung quanh chúng.

Theo các nhà khoa học, những tế bào được cấy melanopsin có khả năng tiếp nhận kích thích ánh sáng và truyền tín hiệu nhìn thấy về não, từ đó những con chuột trên đã nhìn được trở lại.

Theo tác giả chính của nghiên cứu trên, ông Samantha de Silva, “có nhiều bệnh nhân mù lòa và việc giúp họ nhìn được trở lại bằng liệu pháp gene đang khiến cho chúng tôi rất phấn khích. Bước tiếp theo của chúng tôi sẽ là thử nghiệm lâm sàng liệu pháp này ở người”.


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